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Furthermore, the indole Main is substituted at R3 with a carbonyl group that's also bonded into a napthalene moeity. Napthalene is often a bicyclic framework of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it as being a ketone. JWH-018 is definitely an analog of THJ-018, through which the Main indazole construction is substit